Radioimmunoassay of beta-endorphine (RIA) in plasma was performed in patients with acute, subacute and chronic neurosensory hypoacusis. The RIA and audiological examination were made before treatment and after combined therapy consisting of pharmacopuncture and following low-frequency electrostimulation using negative polarity current. The above treatment elevated beta-endorphine levels in blood plasma. Positive results of the treatment correlated with elevated beta-endorphine levels in the end of the treatment.